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#Netspot gallium 68 dotatate generator#

fluid attenuation inversion recovery (FLAIR).

diffusion tensor imaging and fiber tractography.MRI pulse sequences ( basics | abbreviations | parameters).iodinated contrast-induced thyrotoxicosis.iodinated contrast media adverse reactions.clinical applications of dual-energy CT.as low as reasonably achievable (ALARA).(2015) Radiographics : a review publication of the Radiological Society of North America, Inc. Somatostatin receptor imaging with 68Ga DOTATATE PET/CT: clinical utility, normal patterns, pearls, and pitfalls in interpretation. Physiological and tumoral uptake of (68)Ga-DOTATATE: standardized uptake values and challenges in interpretation. Kuyumcu S, Özkan ZG, Sanli Y, Yilmaz E, Mudun A, Adalet I, Unal S. Neuroendocrine Tumor Diagnosis and Management: Ga-DOTATATE PET/CT. Sanli Y, Garg I, Kandathil A, Kendi T, Zanetti MJB, Kuyumcu S, Subramaniam RM. (2007) European journal of nuclear medicine and molecular imaging. Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals?.

Antunes P, Ginj M, Zhang H, Waser B, Baum RP, Reubi JC, Maecke H. (2016) Journal of nuclear medicine : official publication, Society of Nuclear Medicine. Safety and Efficacy of 68Ga-DOTATATE PET/CT for Diagnosis, Staging, and Treatment Management of Neuroendocrine Tumors. Deppen SA, Liu E, Blume JD, Clanton J, Shi C, Jones-Jackson LB, Lakhani V, Baum RP, Berlin J, Smith GT, Graham M, Sandler MP, Delbeke D, Walker RC. The salivary glands and thyroid show faint to mild homogeneous uptake 4,5. There is normal Ga-68 DOTATATE uptake in the pituitary gland, spleen, liver, adrenal glands, and urinary tract 4,5. These have an affinity for different somatostatin receptors, SSTR subtypes 3 and 5 and SSTR subtype 5, respectively 3. It binds SSTR subtype 2 and binds 100 times more avidly than indium-111 pentetreotide 2. Ga-68 DOTATATE has shown improved accuracy for detection relative to indium-111 pentetreotide SPECT-CT 1.

to the short-chain peptide Tyr3-octreotate (TATE).

linked, via a chemical macrocyclic chelator, known as DOTA (or tetraxetan IUPAC name: 1,4,7,10-tetraazacyclododecane-tetraacetic acid).

We believe that the use of NETSPOT should also offer increased comfort for patients by potentially shortening a procedure that is currently performed over 24 hours or more to just a few hours.Gallium-68 DOTATATE is synthesized from three main components: “NETSPOT has the potential to significantly improve the accuracy of NET diagnosis, while reducing radiation exposure for patients. “The FDA approval of NETSPOT is a key milestone in our mission of improving the lives of NET patients,” said Stefano Buono, Chief Executive Officer of AAA.

#Netspot gallium 68 dotatate generator#

NETSPOT is currently approved for use with the GalliaPharm Ga 68 generator from Eckert & Ziegler. AAA intends to commercialize the product in the US in two forms: As a kit for reconstitution using a Ga 68 generator, and as NETSPOT Injection, a ready-to-use dose delivered from a local radiopharmacy in selected metropolitan areas. Gallium Ga 68 dotatate received Orphan Drug Designation from both the FDA and European Medicines Agency (EMA) in March 2014.įollowing today’s approval, NETSPOT will be made available to the US market as soon as possible. NETSPOT is the first approved drug using Ga 68 as a positron emitter. NETSPOT is the new market name for Somakit-TATE (a kit for the preparation of gallium Ga 68 dotatate injection) in the US.

NETSPOT received approval following a Priority Review from the FDA. AAA today announced that the US Food and Drug Administration (FDA) has approved NETSPOT(TM) (Somakit-TATE) for the localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult and pediatric patients.